PCDHB3

Across TCGA cell cohorts, PCDHB3 mutation is significantly associated with the RNA expression of many other genes, with 485 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHB3-associated genes across cancer lineages are CYB5D1, ISOC1, and SPEM3. Each is linked with PCDHB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDHB3-to-partner and partner-to-PCDHB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYB5D1 grouped by PCDHB3-low versus PCDHB3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHB3→partner) and Y-score (partner→PCDHB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CYB5D1 →	+0.844	+3.404	.001	<.001	3	2
LARGE_INTESTINE	ISOC1 →	+0.580	+2.005	.001	.008	3	2
BLOOD_Leukemia	SPEM3 →	+0.012	+4.824	<.001	<.001	3	2
LUNG_SCLC	DTHD1 →	+0.034	+3.523	<.001	.008	3	2
LUNG_SCLC	SPATA31D1 →	+0.506	+4.058	<.001	.007	3	2
KIDNEY	H2AC1 →	+0.093	+5.000	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 485 associations by consensus.

CYB5D1 by PCDHB3 expression — LARGE_INTESTINE

Explore this box plot interactively →