PCDHB2

Across TCGA patient cohorts, PCDHB2 mutation is significantly associated with the RNA expression of many other genes, with 6,073 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHB2-associated genes across cancer lineages are NOP2, ZWINT, and RIOK1. Each is linked with PCDHB2 in more than 4 cancer types. Because this analysis shows association rather than direction, both PCDHB2-to-partner and partner-to-PCDHB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NOP2 grouped by PCDHB2-low versus PCDHB2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHB2→partner) and Y-score (partner→PCDHB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	NOP2 →	+0.473	+2.431	.002	.001	3	5
STAD	ZWINT →	+0.636	+3.609	.003	.001	3	5
STAD	RIOK1 →	+0.350	+2.683	.008	.004	3	5
STAD	PBK →	+0.891	+3.338	.001	.004	3	5
UCEC	RRM2 →	+0.748	+2.357	<.001	<.001	3	5
UCEC	CDCA2 →	+0.731	+1.963	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,073 associations by consensus.

NOP2 by PCDHB2 expression — STAD

Explore this box plot interactively →