PCDHB2

Across TCGA patient cohorts, PCDHB2 mutation is significantly associated with the total protein of many other genes, with 96 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHB2-associated genes across cancer lineages are FoxM1, Cyclin-B1, and Ku80. Each is linked with PCDHB2 in more than 5 cancer types. Because this analysis shows association rather than direction, both PCDHB2-to-partner and partner-to-PCDHB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by PCDHB2-low versus PCDHB2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHB2→partner) and Y-score (partner→PCDHB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FoxM1 →	+0.347	+2.334	<.001	.018	3	6
UCEC	Cyclin-B1 →	+0.665	+1.830	<.001	<.001	3	5
UCEC	Ku80 →	+0.260	+1.948	<.001	<.001	3	4
STAD	mTOR_pS2448 →	-0.136	-3.000	.026	.033	3	4
COAD	Caspase-7-cleavedD198 →	+0.849	+2.000	.001	.029	3	4
LUAD	A-Raf_pS299 →	-0.276	-3.321	.008	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 96 associations by consensus.

FoxM1 by PCDHB2 expression — LUAD

Explore this box plot interactively →