PCDHB2

Across TCGA cell cohorts, PCDHB2 mutation is significantly associated with the RNA expression of many other genes, with 684 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHB2-associated genes across cancer lineages are PYM1, NOA1, and TSPY4. Each is linked with PCDHB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDHB2-to-partner and partner-to-PCDHB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PYM1 grouped by PCDHB2-low versus PCDHB2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHB2→partner) and Y-score (partner→PCDHB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PYM1 →	+0.414	+3.237	.002	.003	3	2
LARGE_INTESTINE	NOA1 →	+0.519	+2.628	.002	.002	3	2
PANCREAS	TSPY4 →	+0.037	+4.614	<.001	.004	3	1
SOFT_TISSUE	CLPS →	+0.114	+4.977	<.001	.002	3	1
SOFT_TISSUE	OR4X2 →	+0.024	+4.369	<.001	.008	3	1
SOFT_TISSUE	MAGEB10 →	+0.649	+4.222	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 684 associations by consensus.

PYM1 by PCDHB2 expression — LARGE_INTESTINE

Explore this box plot interactively →