PCDHB15

Across TCGA patient cohorts, PCDHB15 mutation is significantly associated with the total protein of many other genes, with 65 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHB15-associated genes across cancer lineages are ASNS, TFRC, and Cyclin-B1. Each is linked with PCDHB15 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCDHB15-to-partner and partner-to-PCDHB15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by PCDHB15-low versus PCDHB15-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHB15→partner) and Y-score (partner→PCDHB15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.547	+2.584	<.001	.010	3	4
UCEC	TFRC →	+0.395	+1.999	.005	.008	3	4
UCEC	Cyclin-B1 →	+0.727	+2.039	<.001	<.001	3	4
STAD	PI3K-p110-a →	-0.145	-3.169	.045	.019	3	3
UCEC	Chk2_pT68 →	-0.153	-2.558	.002	<.001	3	3
STAD	4E-BP1 →	+0.408	+3.169	.005	.019	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

ASNS by PCDHB15 expression — COAD

Explore this box plot interactively →