PCDHB15

Across TCGA cell cohorts, PCDHB15 mutation is significantly associated with the RNA expression of many other genes, with 930 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHB15-associated genes across cancer lineages are OR10Q1, RD3L, and MAGEB5. Each is linked with PCDHB15 in more than 2 cancer types. Because this analysis shows association rather than direction, both PCDHB15-to-partner and partner-to-PCDHB15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10Q1 grouped by PCDHB15-low versus PCDHB15-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHB15→partner) and Y-score (partner→PCDHB15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	OR10Q1 →	+0.085	+4.736	<.001	.009	3	3
LUNG_SCLC	RD3L →	+0.018	+5.029	.004	.006	3	2
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
UPPER_AERODIGESTIVE_TRACT	ADAM30 →	+0.043	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	OR4K2 →	+0.163	+5.357	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	GALR1 →	+0.021	+4.736	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 930 associations by consensus.

OR10Q1 by PCDHB15 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →