PCDHB14

Across TCGA patient cohorts, PCDHB14 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHB14-associated genes across cancer lineages are 4E-BP1, STAT3_pY705, and VHL. Each is linked with PCDHB14 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCDHB14-to-partner and partner-to-PCDHB14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by PCDHB14-low versus PCDHB14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHB14→partner) and Y-score (partner→PCDHB14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.284	+4.087	<.001	<.001	3	4
UCEC	STAT3_pY705 →	-0.401	-2.459	<.001	<.001	3	3
UCEC	VHL →	-0.708	-1.643	<.001	.002	3	3
UCEC	C-Raf →	+0.109	+1.459	.007	.011	3	3
LUAD	S6_pS240_S244 →	+0.365	+2.115	.026	.015	3	2
LUSC	Bcl-xL →	+0.179	+3.179	.019	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

4E-BP1 by PCDHB14 expression — UCEC

Explore this box plot interactively →