PCDHB14

Across TCGA cell cohorts, PCDHB14 mutation is significantly associated with the RNA expression of many other genes, with 323 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHB14-associated genes across cancer lineages are HSCB, ACBD5, and BCL7A. Each is linked with PCDHB14 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDHB14-to-partner and partner-to-PCDHB14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSCB grouped by PCDHB14-low versus PCDHB14-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHB14→partner) and Y-score (partner→PCDHB14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HSCB →	+0.479	+3.321	.006	.003	3	2
LARGE_INTESTINE	ACBD5 →	+0.778	+3.169	.001	.006	3	2
LARGE_INTESTINE	BCL7A →	+0.749	+3.321	.002	.003	3	2
LARGE_INTESTINE	MMS22L →	+0.687	+2.129	.003	.007	3	2
LARGE_INTESTINE	SENP3 →	+0.419	+3.389	.009	.001	3	2
LARGE_INTESTINE	E2F7 →	+0.769	+2.129	.003	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 323 associations by consensus.

HSCB by PCDHB14 expression — LARGE_INTESTINE

Explore this box plot interactively →