PCDHB1

Across TCGA cell cohorts, PCDHB1 mutation is significantly associated with the RNA expression of many other genes, with 783 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHB1-associated genes across cancer lineages are SUFU, PNLDC1, and PRR35. Each is linked with PCDHB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PCDHB1-to-partner and partner-to-PCDHB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SUFU grouped by PCDHB1-low versus PCDHB1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHB1→partner) and Y-score (partner→PCDHB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SUFU →	+0.473	+3.082	.004	.007	3	2
SKIN	PNLDC1 →	+0.678	+2.404	.001	<.001	3	2
LARGE_INTESTINE	PRR35 →	+0.057	+2.150	<.001	.005	2	3
LARGE_INTESTINE	CTSS →	-1.898	-2.541	.004	.005	3	2
LARGE_INTESTINE	ISOC1 →	+0.566	+3.743	.003	<.001	3	2
SKIN	MRPL32 →	-0.438	-2.571	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 783 associations by consensus.

SUFU by PCDHB1 expression — SKIN

Explore this box plot interactively →