PCDHAC1

Across TCGA patient cohorts, PCDHAC1 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHAC1-associated genes across cancer lineages are eIF4E, EGFR, and Heregulin. Each is linked with PCDHAC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PCDHAC1-to-partner and partner-to-PCDHAC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PCDHAC1-low versus PCDHAC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHAC1→partner) and Y-score (partner→PCDHAC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.194	+3.713	.003	<.001	3	3
UCEC	EGFR →	-0.135	-1.584	.007	.034	3	2
UCEC	Heregulin →	-0.097	-1.986	.012	.029	3	2
UCEC	Lck →	+0.138	+1.137	.028	.041	3	2
UCEC	p62 Lck ligand →	+0.469	+2.115	<.001	<.001	3	2
COAD	PCNA →	+0.266	+2.467	.013	.011	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

eIF4E by PCDHAC1 expression — UCEC

Explore this box plot interactively →