PCDHAC1

Across TCGA cell cohorts, PCDHAC1 mutation is significantly associated with the RNA expression of many other genes, with 141 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHAC1-associated genes across cancer lineages are MMP26, ASIP, and NPHS2. Each is linked with PCDHAC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDHAC1-to-partner and partner-to-PCDHAC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMP26 grouped by PCDHAC1-low versus PCDHAC1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHAC1→partner) and Y-score (partner→PCDHAC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MMP26 →	+0.011	+3.700	<.001	.009	3	2
LARGE_INTESTINE	ASIP →	+0.183	+3.304	.002	.005	3	2
BLOOD_Leukemia	NPHS2 →	+0.113	+3.705	<.001	.007	3	1
BLOOD_Leukemia	ADIG →	+0.018	+4.984	<.001	.002	3	1
BLOOD_Leukemia	CCDC172 →	+0.083	+6.201	<.001	<.001	3	1
BLOOD_Leukemia	LCE2A →	+0.042	+4.384	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 141 associations by consensus.

MMP26 by PCDHAC1 expression — SKIN

Explore this box plot interactively →