Across TCGA patient cohorts, PCDHA8 mutation is significantly associated with the RNA expression of many other genes, with 6,583 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHA8-associated genes across cancer lineages are ZWINT, HJURP, and PSMC3IP. Each is linked with PCDHA8 in more than 4 cancer types. Because this analysis shows association rather than direction, both PCDHA8-to-partner and partner-to-PCDHA8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHA8→partner) and Y-score (partner→PCDHA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZWINT →	+0.625	+1.657	<.001	<.001	3	5
UCEC	HJURP →	+0.391	+1.121	.007	.005	3	5
UCEC	PSMC3IP →	+0.579	+1.525	<.001	<.001	3	5
UCEC	KIF2C →	+0.540	+1.525	<.001	<.001	3	5
UCEC	CDCA5 →	+0.689	+1.818	<.001	<.001	3	5
SKCM	E2F7 →	+0.584	+1.648	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,583 associations by consensus.

Exploration

PCDHA8 survival (RNA) · tumor vs normal (RNA) · all PCDHA8 data types