Across TCGA patient cohorts, PCDHA8 mutation is significantly associated with the total protein of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHA8-associated genes across cancer lineages are ASNS, PAI-1, and FASN. Each is linked with PCDHA8 in more than 4 cancer types. Because this analysis shows association rather than direction, both PCDHA8-to-partner and partner-to-PCDHA8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHA8→partner) and Y-score (partner→PCDHA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.428	+1.745	<.001	.004	3	5
COAD	PAI-1 →	+0.440	+2.186	.017	.032	3	5
COAD	FASN →	+0.318	+1.178	.009	.043	3	4
STAD	FOXO3a_pS318_S321 →	-0.201	-2.807	.001	.002	3	4
COAD	Caspase-7-cleavedD198 →	+0.777	+3.824	.001	<.001	3	4
COAD	Di-Ras3 →	-0.133	-1.874	.029	.049	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

Exploration

PCDHA8 survival (RNA) · tumor vs normal (RNA) · all PCDHA8 data types