PCDHA6

Across TCGA patient cohorts, PCDHA6 mutation is significantly associated with the total protein of many other genes, with 74 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHA6-associated genes across cancer lineages are 4E-BP1, 14-3-3_beta, and JNK_pT183_Y185. Each is linked with PCDHA6 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCDHA6-to-partner and partner-to-PCDHA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by PCDHA6-low versus PCDHA6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHA6→partner) and Y-score (partner→PCDHA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.291	+2.874	<.001	<.001	3	4
BLCA	14-3-3_beta →	-0.112	-3.442	.036	.005	3	3
COAD	JNK_pT183_Y185 →	-0.169	-1.576	.032	.009	3	3
LUAD	p90 RSK_pT359_S363 →	-0.148	-1.700	.021	.043	3	3
UCEC	eIF4E →	+0.152	+2.013	.005	.004	3	3
UCEC	STAT3_pY705 →	-0.231	-1.064	<.001	.038	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

4E-BP1 by PCDHA6 expression — UCEC

Explore this box plot interactively →