PCDHA6

Across TCGA cell cohorts, PCDHA6 mutation is significantly associated with the RNA expression of many other genes, with 734 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHA6-associated genes across cancer lineages are DMC1, FBXO6, and SCO1. Each is linked with PCDHA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDHA6-to-partner and partner-to-PCDHA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DMC1 grouped by PCDHA6-low versus PCDHA6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHA6→partner) and Y-score (partner→PCDHA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DMC1 →	+0.795	+1.850	<.001	.006	3	2
LARGE_INTESTINE	FBXO6 →	+1.267	+3.321	<.001	.002	3	2
LARGE_INTESTINE	SCO1 →	+0.489	+1.850	.005	.006	3	2
LARGE_INTESTINE	ESR2 →	+0.292	+2.451	<.001	<.001	3	2
LARGE_INTESTINE	TICRR →	+0.628	+2.364	<.001	<.001	3	2
LARGE_INTESTINE	NDUFB10 →	+0.437	+2.652	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 734 associations by consensus.

DMC1 by PCDHA6 expression — LARGE_INTESTINE

Explore this box plot interactively →