PCDHA6

Across TCGA cell cohorts, PCDHA6 mutation is significantly associated with the mutation status of many other genes, with 3,759 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHA6-associated genes across cancer lineages are PIGN, HELZ2, and EVPL. Each is linked with PCDHA6 in more than 4 cancer types. Because this analysis shows association rather than direction, both PCDHA6-to-partner and partner-to-PCDHA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIGN grouped by PCDHA6-low versus PCDHA6-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHA6→partner) and Y-score (partner→PCDHA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PIGN →	+4.662	+3.339	.003	.003	1	5
SKIN	HELZ2 →	+1.768	+1.869	.007	.007	1	5
SOFT_TISSUE	EVPL →	+2.985	+3.562	.008	.008	1	5
STOMACH	COL7A1 →	+2.942	+4.025	.009	.009	1	5
LARGE_INTESTINE	LYST →	+2.180	+2.395	<.001	<.001	1	5
SOFT_TISSUE	OR7D4 →	+4.307	+4.307	.001	.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,759 associations by consensus.

PIGN by PCDHA6 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →