Across TCGA patient cohorts, PCDHA4 mutation is significantly associated with the RNA expression of many other genes, with 5,831 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHA4-associated genes across cancer lineages are MFSD12, TAF13, and TXNRD1. Each is linked with PCDHA4 in more than 4 cancer types. Because this analysis shows association rather than direction, both PCDHA4-to-partner and partner-to-PCDHA4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHA4→partner) and Y-score (partner→PCDHA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MFSD12 →	+0.340	+1.517	<.001	<.001	3	5
LUAD	TAF13 →	+0.479	+2.744	<.001	.003	3	4
STAD	TXNRD1 →	+0.599	+2.807	<.001	.003	3	4
UCEC	WDHD1 →	+0.373	+1.021	.003	.007	3	4
UCEC	LINC00865 →	-0.459	-1.357	.002	<.001	3	4
SKCM	TSPY26P →	-0.564	-1.395	.004	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,831 associations by consensus.

Exploration

PCDHA4 survival (RNA) · tumor vs normal (RNA) · all PCDHA4 data types