Across TCGA patient cohorts, PCDHA4 mutation is significantly associated with the total protein of many other genes, with 93 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHA4-associated genes across cancer lineages are Caspase-7-cleavedD198, GAPDH, and eEF2. Each is linked with PCDHA4 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCDHA4-to-partner and partner-to-PCDHA4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHA4→partner) and Y-score (partner→PCDHA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.076	+3.476	<.001	.002	3	4
LUAD	GAPDH →	+0.640	+2.459	.006	.018	3	4
STAD	eEF2 →	+0.427	+2.700	<.001	.005	3	4
UCEC	VEGFR2 →	+0.194	+1.120	.020	.013	3	4
LUSC	MYH11 →	-0.805	-3.000	.030	.033	3	3
LUSC	Akt_pS473 →	-0.558	-2.106	.008	.018	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 93 associations by consensus.

Exploration

PCDHA4 survival (RNA) · tumor vs normal (RNA) · all PCDHA4 data types