Across TCGA patient cohorts, PCDHA2 mutation is significantly associated with the total protein of many other genes, with 72 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHA2-associated genes across cancer lineages are mTOR_pS2448, ASNS, and p38-MAPK. Each is linked with PCDHA2 in more than 5 cancer types. Because this analysis shows association rather than direction, both PCDHA2-to-partner and partner-to-PCDHA2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHA2→partner) and Y-score (partner→PCDHA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	mTOR_pS2448 →	-0.136	-1.064	.014	.045	3	6
UCEC	ASNS →	+0.330	+1.237	<.001	.004	3	4
LUSC	p38-MAPK →	-0.142	-1.860	.010	.049	3	3
LUAD	AMPK_pT172 →	-0.455	-1.700	<.001	.040	3	3
LUAD	ACC_pS79 →	-0.303	-1.874	.015	.049	3	3
LUAD	STAT3_pY705 →	-0.307	-2.459	.001	.017	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

Exploration

PCDHA2 survival (RNA) · tumor vs normal (RNA) · all PCDHA2 data types