PCDHA11

Across TCGA patient cohorts, PCDHA11 mutation is significantly associated with the total protein of many other genes, with 77 significant associations in total. COAD shows the largest number of these associations.

The most reproducible PCDHA11-associated genes across cancer lineages are Caspase-7-cleavedD198, Cyclin-B1, and cIAP. Each is linked with PCDHA11 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCDHA11-to-partner and partner-to-PCDHA11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PCDHA11-low versus PCDHA11-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHA11→partner) and Y-score (partner→PCDHA11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.097	+2.815	<.001	<.001	3	4
COAD	Cyclin-B1 →	+0.432	+1.923	.005	.007	3	4
COAD	cIAP →	+0.102	+2.175	.004	<.001	3	4
LUAD	C-Raf →	+0.200	+2.841	.001	.035	3	3
STAD	PREX1 →	+0.174	+1.765	.029	.012	3	3
STAD	YAP_pS127 →	-0.324	-1.684	.003	.038	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

Caspase-7-cleavedD198 by PCDHA11 expression — COAD

Explore this box plot interactively →