Across TCGA cell cohorts, PCDHA1 mutation is significantly associated with the RNA expression of many other genes, with 896 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHA1-associated genes across cancer lineages are SH3GL2, CRYBG1, and COMMD2. Each is linked with PCDHA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDHA1-to-partner and partner-to-PCDHA1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHA1→partner) and Y-score (partner→PCDHA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SH3GL2 →	+0.906	+3.628	.006	<.001	3	2
BLOOD_Leukemia	CRYBG1 →	+1.399	+2.489	.007	.007	3	2
BLOOD_Leukemia	COMMD2 →	+0.568	+2.548	.002	.006	3	2
BLOOD_Leukemia	PPP6C →	+0.393	+3.263	.008	.005	3	2
LARGE_INTESTINE	SMU1 →	+0.439	+3.714	<.001	<.001	3	2
BLOOD_Leukemia	EXOSC9 →	+0.444	+3.176	.003	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 896 associations by consensus.

Exploration

PCDHA1 survival (RNA) · tumor vs normal (RNA) · all PCDHA1 data types