Across TCGA patient cohorts, PCDH9 mutation is significantly associated with the total protein of many other genes, with 79 significant associations in total. STAD shows the largest number of these associations.

The most reproducible PCDH9-associated genes across cancer lineages are HER2, Caspase-7-cleavedD198, and 4E-BP1. Each is linked with PCDH9 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCDH9-to-partner and partner-to-PCDH9 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDH9→partner) and Y-score (partner→PCDH9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	HER2 →	+0.409	+2.468	.011	.011	3	4
STAD	Caspase-7-cleavedD198 →	+0.538	+3.321	.033	.008	3	4
STAD	4E-BP1 →	+0.311	+3.584	.002	.002	3	4
LUSC	Bcl-2 →	-0.375	-3.156	.018	.018	3	3
LUSC	c-Kit →	-0.415	-3.000	.034	.035	3	3
COAD	eEF2 →	+0.225	+2.204	.024	.031	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

Exploration

PCDH9 survival (RNA) · tumor vs normal (RNA) · all PCDH9 data types