PCDH7

Across TCGA patient cohorts, PCDH7 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDH7-associated genes across cancer lineages are PAI-1, PKC-b-II_pS660, and S6_pS240_S244. Each is linked with PCDH7 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCDH7-to-partner and partner-to-PCDH7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAI-1 grouped by PCDH7-low versus PCDH7-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDH7→partner) and Y-score (partner→PCDH7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	PAI-1 →	+0.954	+2.179	.002	.035	3	3
LUSC	PKC-b-II_pS660 →	-0.403	-3.000	.008	.035	3	3
LUSC	S6_pS240_S244 →	-0.635	-3.312	.009	.010	3	3
BLCA	ER-alpha_pS118 →	+0.179	+3.012	.001	.018	2	4
UCEC	Rad50 →	-0.184	-2.308	.038	.033	3	3
UCEC	CD20 →	+0.120	+2.135	.012	.010	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

PAI-1 by PCDH7 expression — LUSC

Explore this box plot interactively →