PCDH20

Across TCGA patient cohorts, PCDH20 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. SCLC shows the largest number of these associations.

The most reproducible PCDH20-associated genes across cancer lineages are NPVF, LCE3D, and OR14C36. Each is linked with PCDH20 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDH20-to-partner and partner-to-PCDH20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPVF grouped by PCDH20-low versus PCDH20-high in SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDH20→partner) and Y-score (partner→PCDH20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	NPVF →	+0.069	+4.847	<.001	.009	3	1
SCLC	LCE3D →	+0.215	+6.228	<.001	.001	3	1
SCLC	OR14C36 →	+0.098	+4.847	<.001	.009	3	1
SCLC	ACTL9 →	+0.156	+4.847	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

NPVF by PCDH20 expression — SCLC

Explore this box plot interactively →