PCDH20

Across TCGA cell cohorts, PCDH20 mutation is significantly associated with the RNA expression of many other genes, with 628 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDH20-associated genes across cancer lineages are CCR8, GZMK, and EFCAB3. Each is linked with PCDH20 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDH20-to-partner and partner-to-PCDH20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCR8 grouped by PCDH20-low versus PCDH20-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDH20→partner) and Y-score (partner→PCDH20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CCR8 →	+0.016	+4.369	<.001	.008	3	1
PANCREAS	GZMK →	+0.006	+5.614	<.001	.002	3	1
PANCREAS	EFCAB3 →	+0.036	+5.614	<.001	.002	3	1
PANCREAS	FOXR2 →	+0.006	+5.000	<.001	.006	3	1
BREAST	OR52E8 →	+0.047	+4.199	<.001	.007	3	1
STOMACH	NLRP5 →	+0.525	+3.632	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 628 associations by consensus.

CCR8 by PCDH20 expression — SOFT_TISSUE

Explore this box plot interactively →