Across TCGA patient cohorts, PCDH18 mutation is significantly associated with the total protein of many other genes, with 70 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDH18-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and Myosin-IIa_pS1943. Each is linked with PCDH18 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCDH18-to-partner and partner-to-PCDH18 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDH18→partner) and Y-score (partner→PCDH18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.544	-1.874	<.001	<.001	3	4
COAD	Caspase-7-cleavedD198 →	+1.012	+3.584	<.001	.002	3	4
STAD	Myosin-IIa_pS1943 →	+0.481	+3.169	.015	.017	3	3
UCEC	eIF4E →	+0.177	+1.874	.002	<.001	3	3
UCEC	GAPDH →	+0.376	+1.502	.011	.025	3	3
SKCM	PREX1 →	-0.181	-0.906	.025	.031	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

Exploration

PCDH18 survival (RNA) · tumor vs normal (RNA) · all PCDH18 data types