Across TCGA cell cohorts, PCDH18 mutation is significantly associated with the RNA expression of many other genes, with 308 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDH18-associated genes across cancer lineages are BORCS5, CPXCR1, and LEPROTL1. Each is linked with PCDH18 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDH18-to-partner and partner-to-PCDH18 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDH18→partner) and Y-score (partner→PCDH18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BORCS5 →	+0.509	+3.321	.001	.002	3	2
BLOOD_Leukemia	CPXCR1 →	+0.075	+3.971	<.001	.002	3	2
SKIN	LEPROTL1 →	+0.485	+3.169	.003	.009	3	2
PANCREAS	TBX22 →	+0.083	+5.614	<.001	.002	3	1
PANCREAS	OLIG3 →	+0.006	+5.000	<.001	.006	3	1
PANCREAS	GFRAL →	+0.006	+5.614	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 308 associations by consensus.

Exploration

PCDH18 survival (RNA) · tumor vs normal (RNA) · all PCDH18 data types