PCDH12

Across TCGA patient cohorts, PCDH12 mutation is significantly associated with the RNA expression of many other genes, with 4,042 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDH12-associated genes across cancer lineages are MYO19, FCER1A, and SHMT2. Each is linked with PCDH12 in more than 4 cancer types. Because this analysis shows association rather than direction, both PCDH12-to-partner and partner-to-PCDH12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYO19 grouped by PCDH12-low versus PCDH12-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDH12→partner) and Y-score (partner→PCDH12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MYO19 →	+0.372	+3.489	.008	.002	3	5
UCEC	FCER1A →	-0.723	-2.087	<.001	<.001	3	4
UCEC	SHMT2 →	+0.548	+2.091	<.001	<.001	3	4
UCEC	FANCA →	+0.645	+2.343	<.001	<.001	3	4
UCEC	TMEM120B →	+0.241	+1.526	.006	.001	3	4
UCEC	TMX2 →	+0.363	+1.332	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,042 associations by consensus.

MYO19 by PCDH12 expression — COAD

Explore this box plot interactively →