PCDH12

Across TCGA patient cohorts, PCDH12 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDH12-associated genes across cancer lineages are C-Raf, INPP4B, and Notch1. Each is linked with PCDH12 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCDH12-to-partner and partner-to-PCDH12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by PCDH12-low versus PCDH12-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDH12→partner) and Y-score (partner→PCDH12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	C-Raf →	+0.167	+2.178	.015	.035	3	4
UCEC	INPP4B →	-0.290	-2.662	.002	<.001	3	3
UCEC	Notch1 →	+0.133	+2.100	.001	.002	3	3
UCEC	PKC-b-II_pS660 →	-0.180	-1.184	.029	.022	3	3
COAD	Shc_pY317 →	-0.175	-2.983	.026	.034	3	3
UCEC	TFRC →	+0.389	+1.184	.014	.022	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

C-Raf by PCDH12 expression — COAD

Explore this box plot interactively →