PCDH12

Across TCGA cell cohorts, PCDH12 mutation is significantly associated with the RNA expression of many other genes, with 721 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDH12-associated genes across cancer lineages are RBMY1A1, NPVF, and GLYATL3. Each is linked with PCDH12 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDH12-to-partner and partner-to-PCDH12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBMY1A1 grouped by PCDH12-low versus PCDH12-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDH12→partner) and Y-score (partner→PCDH12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RBMY1A1 →	+0.705	+3.824	.004	.001	3	2
KIDNEY	NPVF →	+0.020	+5.000	<.001	.005	3	1
KIDNEY	GLYATL3 →	+0.043	+5.000	<.001	.005	3	1
KIDNEY	KLF18 →	+0.006	+5.000	<.001	.005	3	1
LARGE_INTESTINE	GCAT →	+1.169	+3.584	<.001	<.001	3	1
LARGE_INTESTINE	DEPDC5 →	+0.495	+2.584	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 721 associations by consensus.

RBMY1A1 by PCDH12 expression — BLOOD_Leukemia

Explore this box plot interactively →