PCDH11Y

Across TCGA patient cohorts, PCDH11Y mutation is significantly associated with the RNA expression of many other genes, with 873 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible PCDH11Y-associated genes across cancer lineages are TBL1Y, AMELY, and ARSDP1. Each is linked with PCDH11Y in more than 3 cancer types. Because this analysis shows association rather than direction, both PCDH11Y-to-partner and partner-to-PCDH11Y results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBL1Y grouped by PCDH11Y-low versus PCDH11Y-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDH11Y→partner) and Y-score (partner→PCDH11Y) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	TBL1Y →	+0.877	+4.857	<.001	<.001	3	4
LUAD	AMELY →	+0.317	+2.584	<.001	.003	3	4
COAD	ARSDP1 →	+0.356	+2.880	.004	.003	3	4
LUAD	HSFY3P →	+0.143	+5.115	<.001	<.001	3	4
LIHC	ZNF885P →	+0.046	+2.433	<.001	.004	3	4
LUAD	NAP1L1P2 →	+0.116	+2.935	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 873 associations by consensus.

TBL1Y by PCDH11Y expression — LUSC

Explore this box plot interactively →