PCDH11Y

Across TCGA patient cohorts, PCDH11Y mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible PCDH11Y-associated genes across cancer lineages are ER-alpha_pS118, p38-MAPK_pT180_Y182, and c-Kit. Each is linked with PCDH11Y in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDH11Y-to-partner and partner-to-PCDH11Y results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-alpha_pS118 grouped by PCDH11Y-low versus PCDH11Y-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDH11Y→partner) and Y-score (partner→PCDH11Y) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	ER-alpha_pS118 →	+0.083	+2.473	.011	.010	3	2
SKCM	p38-MAPK_pT180_Y182 →	-0.318	-2.000	.041	.031	3	2
SKCM	c-Kit →	-0.576	-2.321	.049	.032	3	2
COAD	4E-BP1 →	+0.246	+2.815	.041	.036	3	2
STAD	CD31 →	-0.234	-3.000	.002	.034	2	2
LUSC	Axl →	-0.146	-1.858	.024	.048	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

ER-alpha_pS118 by PCDH11Y expression — LUSC

Explore this box plot interactively →