PCDH11Y

Across TCGA cell cohorts, PCDH11Y mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PCDH11Y-associated genes across cancer lineages are ZP4, UBE2U, and DPPA5. Each is linked with PCDH11Y in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDH11Y-to-partner and partner-to-PCDH11Y results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZP4 grouped by PCDH11Y-low versus PCDH11Y-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDH11Y→partner) and Y-score (partner→PCDH11Y) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ZP4 →	+0.010	+4.643	<.001	.004	3	1
LUNG_NSCLC_LUAD	UBE2U →	+0.167	+4.371	<.001	.005	3	1
LUNG_NSCLC_LUAD	DPPA5 →	+0.081	+4.544	<.001	.003	3	1
LUNG_NSCLC_LUAD	RBMY1A1 →	+1.066	+4.371	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ZP4 by PCDH11Y expression — LUNG_SCLC

Explore this box plot interactively →