PCDH10

Across TCGA patient cohorts, PCDH10 mutation is significantly associated with the total protein of many other genes, with 123 significant associations in total. STAD shows the largest number of these associations.

The most reproducible PCDH10-associated genes across cancer lineages are Cyclin-B1, eEF2, and ASNS. Each is linked with PCDH10 in more than 4 cancer types. Because this analysis shows association rather than direction, both PCDH10-to-partner and partner-to-PCDH10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by PCDH10-low versus PCDH10-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDH10→partner) and Y-score (partner→PCDH10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Cyclin-B1 →	+0.568	+2.459	<.001	<.001	3	5
STAD	eEF2 →	+0.458	+2.459	<.001	<.001	3	5
STAD	ASNS →	+0.419	+1.736	.002	.006	3	5
UCEC	p38-MAPK_pT180_Y182 →	-0.229	-0.816	.048	.049	3	4
UCEC	A-Raf_pS299 →	-0.097	-1.353	.001	.013	3	4
STAD	Caspase-7-cleavedD198 →	+0.868	+2.584	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 123 associations by consensus.

Cyclin-B1 by PCDH10 expression — STAD

Explore this box plot interactively →