PCBP1

Across TCGA patient cohorts, PCBP1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCBP1-associated genes across cancer lineages are JNK_pT183_Y185, MEK1, and SF2. Each is linked with PCBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCBP1-to-partner and partner-to-PCBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by PCBP1-low versus PCBP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCBP1→partner) and Y-score (partner→PCBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.247	-3.156	.007	.020	3	1
UCEC	MEK1 →	+0.442	+3.169	.027	.020	3	1
UCEC	SF2 →	-0.142	-2.990	.018	.036	3	1
UCEC	VHL →	-1.271	-3.169	<.001	.020	3	1
UCEC	Cyclin-E2 →	+0.270	+2.817	.003	.036	3	1
UCEC	Di-Ras3 →	-0.257	-3.000	.001	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

JNK_pT183_Y185 by PCBP1 expression — UCEC

Explore this box plot interactively →