PCBD2

Across TCGA patient cohorts, PCBD2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCBD2-associated genes across cancer lineages are Shc_pY317, Di-Ras3, and FoxM1. Each is linked with PCBD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCBD2-to-partner and partner-to-PCBD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by PCBD2-low versus PCBD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCBD2→partner) and Y-score (partner→PCBD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.218	-3.169	.008	.020	3	1
UCEC	Di-Ras3 →	-0.176	-3.000	.031	.036	3	1
UCEC	FoxM1 →	+0.303	+3.169	.033	.020	2	1
UCEC	VHL →	-1.260	-3.000	<.001	.036	2	1
UCEC	INPP4B →	-0.410	-3.156	.021	.020	1	1
UCEC	Tuberin →	+0.431	+3.169	.003	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Shc_pY317 by PCBD2 expression — UCEC

Explore this box plot interactively →