PCAT5

Across TCGA pan-cancer cohorts, PCAT5 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of PCAT5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where PCAT5 RNA is repressed in tumor relative to normal tissue. In most cancer types PCAT5 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KICH, HNSC, and BRCA are the cancer types where PCAT5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PCAT5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	−0.035	<.001	7	view →
HNSC	All	All	+0.016	.009	7	view →
BRCA	All	III,IV	−0.063	<.001	6	view →
KIRP	Male	III,IV	+0.039	.029	5	view →
LUSC	All	All	+0.052	<.001	3	view →
KIRC	Male	IV	+0.039	.002	3	view →
THCA	All	All	−0.022	.001	3	view →
PRAD	All	All	+0.515	<.001	2	view →
BRCA	All	IV	+0.110	.031	2	view →
LUAD	All	All	+0.041	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 9 lineages.

PCAT5–KICH

Open the KICH breakdown →