PCAT4

Across TCGA pan-cancer cohorts, PCAT4 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of PCAT4’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where PCAT4 RNA is repressed in tumor relative to normal tissue. In most cancer types PCAT4 is over-expressed in tumor, although a few such as BRCA and KIRP show the opposite, repressed pattern.

BRCA, KIRP, and THCA are the cancer types where PCAT4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PCAT4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	Female	II,III,IV	−0.024	.001	6	view →
KIRP	All	All	−0.013	.035	2	view →
THCA	All	All	−0.007	.007	2	view →
READ	All	II,III,IV	−0.035	.038	1	view →
STAD	Male	All	−0.026	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

PCAT4–BRCA

Open the BRCA breakdown →