PCARE

Across TCGA patient cohorts, PCARE mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCARE-associated genes across cancer lineages are Notch1, PCNA, and ATM. Each is linked with PCARE in more than 3 cancer types. Because this analysis shows association rather than direction, both PCARE-to-partner and partner-to-PCARE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by PCARE-low versus PCARE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCARE→partner) and Y-score (partner→PCARE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.155	+2.820	<.001	.001	3	3
UCEC	PCNA →	+0.184	+1.807	.007	.024	3	3
COAD	ATM →	-0.466	-3.000	.011	.035	3	3
UCEC	Cyclin-B1 →	+0.640	+3.700	<.001	.001	3	3
SKCM	ASNS →	+0.272	+1.321	.038	.011	3	3
LUSC	C-Raf →	+0.238	+2.853	<.001	.034	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Notch1 by PCARE expression — UCEC

Explore this box plot interactively →