PCARE

Across TCGA cell cohorts, PCARE mutation is significantly associated with the RNA expression of many other genes, with 506 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCARE-associated genes across cancer lineages are LILRA5, MND1, and SDC4. Each is linked with PCARE in more than 1 cancer types. Because this analysis shows association rather than direction, both PCARE-to-partner and partner-to-PCARE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LILRA5 grouped by PCARE-low versus PCARE-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCARE→partner) and Y-score (partner→PCARE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	LILRA5 →	+0.043	+3.772	<.001	.008	3	2
LARGE_INTESTINE	MND1 →	+0.753	+2.043	.001	.008	3	2
LARGE_INTESTINE	SDC4 →	-1.507	-3.459	<.001	<.001	3	2
LARGE_INTESTINE	CCDC62 →	+0.201	+3.169	.001	.006	3	2
LARGE_INTESTINE	RSAD1 →	+0.727	+2.743	<.001	.001	3	2
LARGE_INTESTINE	CHCHD4 →	+0.493	+3.169	.003	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 506 associations by consensus.

LILRA5 by PCARE expression — CNS

Explore this box plot interactively →