PC

Across TCGA pan-cancer cohorts, PC mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PC data layer compared with 24 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PC mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PC expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

LSCC, HNSC, and PDAC are the cancer types where PC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	1.000	0.537	.006	41	view →
HNSC	DFS	Median	All	0.756	0.543	.007	14	view →
PDAC	OS	Median	III,IV	0.537	1.000	.008	10	view →
CCRCC	OS	Median	All	0.984	0.901	.020	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PC–LSCC (DFS)

Open the LSCC breakdown →