PC

Across TCGA patient cohorts, PC mutation is significantly associated with the RNA expression of many other genes, with 6,261 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PC-associated genes across cancer lineages are INCENP, CHEK1, and LMNB2. Each is linked with PC in more than 3 cancer types. Because this analysis shows association rather than direction, both PC-to-partner and partner-to-PC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INCENP grouped by PC-low versus PC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PC→partner) and Y-score (partner→PC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INCENP →	+0.477	+2.201	.002	.001	3	4
UCEC	CHEK1 →	+0.486	+2.108	<.001	.002	3	4
UCEC	LMNB2 →	+0.576	+1.722	<.001	<.001	3	4
UCEC	DIAPH3 →	+0.817	+1.733	<.001	<.001	3	4
UCEC	PLCB3 →	+0.346	+1.604	.001	<.001	3	3
UCEC	HIRIP3 →	+0.356	+4.096	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,261 associations by consensus.

INCENP by PC expression — UCEC

Explore this box plot interactively →