PC

Across TCGA cell cohorts, PC mutation is significantly associated with the RNA expression of many other genes, with 432 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PC-associated genes across cancer lineages are MFSD6L, RGSL1, and GRM6. Each is linked with PC in more than 1 cancer types. Because this analysis shows association rather than direction, both PC-to-partner and partner-to-PC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MFSD6L grouped by PC-low versus PC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PC→partner) and Y-score (partner→PC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MFSD6L →	+0.663	+3.087	<.001	.006	3	2
KIDNEY	RGSL1 →	+0.043	+5.000	<.001	.005	3	1
SKIN	GRM6 →	+0.038	+3.347	.001	.005	3	1
SKIN	GALR1 →	+0.648	+4.022	<.001	.006	3	1
SKIN	OR5A1 →	+0.010	+4.022	<.001	.006	3	1
SKIN	SPATA45 →	+0.136	+3.748	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 432 associations by consensus.

MFSD6L by PC expression — LARGE_INTESTINE

Explore this box plot interactively →