PBX3

Across TCGA pan-cancer cohorts, PBX3 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated PBX3 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PBX3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PBX3 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

UCEC and PDAC are the cancer types where PBX3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	All	0.767	1.000	.002	4	view →
PDAC	OS	Median	All	0.933	0.547	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

PBX3–UCEC (DFS)

Open the UCEC breakdown →