PBX3

Across TCGA patient cohorts, PBX3 mutation is significantly associated with the RNA expression of many other genes, with 2,755 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PBX3-associated genes across cancer lineages are LINC00351, CCL27, and LINC01904. Each is linked with PBX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PBX3-to-partner and partner-to-PBX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC00351 grouped by PBX3-low versus PBX3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PBX3→partner) and Y-score (partner→PBX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	LINC00351 →	+0.216	+3.694	.005	.005	3	2
LUAD	CCL27 →	+0.046	+5.739	<.001	.001	3	2
LUAD	LINC01904 →	+0.096	+5.444	<.001	.002	3	2
UCEC	RNA5SP412 →	+0.321	+1.619	.003	.002	3	2
BLCA	OR4G6P →	+0.044	+7.640	<.001	.009	3	2
COAD	BPY2DP →	+0.252	+5.994	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,755 associations by consensus.

LINC00351 by PBX3 expression — LUSC

Explore this box plot interactively →