PBX3

Across TCGA patient cohorts, PBX3 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PBX3-associated genes across cancer lineages are eIF4E, PCNA, and ASNS. Each is linked with PBX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PBX3-to-partner and partner-to-PBX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PBX3-low versus PBX3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PBX3→partner) and Y-score (partner→PBX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.149	+2.013	.019	.004	3	2
UCEC	PCNA →	+0.145	+1.807	.026	.024	3	2
UCEC	ASNS →	+0.325	+1.514	.002	.014	3	2
UCEC	ATM →	-0.494	-3.074	<.001	<.001	3	2
UCEC	eIF4G →	+0.242	+1.321	.009	.012	3	1
UCEC	FoxM1 →	+0.184	+1.125	.018	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

eIF4E by PBX3 expression — UCEC

Explore this box plot interactively →