PBX3

Across TCGA cell cohorts, PBX3 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PBX3-associated genes across cancer lineages are GPRIN2, H2BC1, and H2AC1. Each is linked with PBX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PBX3-to-partner and partner-to-PBX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPRIN2 grouped by PBX3-low versus PBX3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PBX3→partner) and Y-score (partner→PBX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GPRIN2 →	+0.424	+3.648	.003	.002	3	2
SOFT_TISSUE	H2BC1 →	+0.433	+5.977	<.001	.001	3	1
SOFT_TISSUE	H2AC1 →	+0.193	+5.977	<.001	.001	3	1
SOFT_TISSUE	KRTAP10-1 →	+0.034	+5.369	.002	.004	3	1
SOFT_TISSUE	GAGE12E →	+0.090	+4.930	<.001	.008	3	1
BLOOD_Leukemia	GUCA1C →	+0.024	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

GPRIN2 by PBX3 expression — SKIN

Explore this box plot interactively →