Across TCGA patient cohorts, PBX2 mutation is significantly associated with the RNA expression of many other genes, with 2,925 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PBX2-associated genes across cancer lineages are LINC02559, MIR4757, and MTERF3. Each is linked with PBX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PBX2-to-partner and partner-to-PBX2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PBX2→partner) and Y-score (partner→PBX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	LINC02559 →	+1.025	+5.342	<.001	.002	3	2
HNSC	MIR4757 →	+1.156	+6.111	<.001	.002	3	2
BLCA	MTERF3 →	+0.678	+3.249	<.001	.009	3	2
UCEC	AIMP1 →	+0.487	+2.436	<.001	.002	3	2
BLCA	RNU6-85P →	+0.235	+3.566	<.001	.003	3	2
UCEC	SNORA74C-1 →	+0.262	+2.519	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,925 associations by consensus.

Exploration

PBX2 survival (RNA) · tumor vs normal (RNA) · all PBX2 data types