Across TCGA cell cohorts, PBX2 mutation is significantly associated with the drug of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PBX2-associated genes across cancer lineages are GSK2276186C, 123829, and Sinularin. Each is linked with PBX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PBX2-to-partner and partner-to-PBX2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PBX2→partner) and Y-score (partner→PBX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GSK2276186C →	+0.551	+2.871	.011	.021	3	1
LARGE_INTESTINE	123829 →	+0.713	+2.871	.008	.021	3	1
LARGE_INTESTINE	Sinularin →	+0.304	+3.000	.042	.017	3	1
LARGE_INTESTINE	T0901317 →	+0.261	+2.944	.047	.018	3	1
LARGE_INTESTINE	Bosutinib →	+0.424	+2.807	.016	.046	2	1
LARGE_INTESTINE	Doramapimod →	+0.330	+2.807	.026	.046	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

PBX2 survival (RNA) · tumor vs normal (RNA) · all PBX2 data types