PBOV1

Across TCGA cell cohorts, PBOV1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,374 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible PBOV1-associated GO terms across cancer lineages are Negative regulation of actin nucleation, Establishment of epithelial cell apical/basal polarity, and ER-nucleus signaling pathway. Each is linked with PBOV1 in more than 5 cancer types. Because this analysis shows association rather than direction, both PBOV1-to-partner and partner-to-PBOV1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of actin nucleation grouped by PBOV1-low versus PBOV1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PBOV1→partner) and Y-score (partner→PBOV1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of actin nucleation →	+0.172	+0.120	<.001	.003	3	6
LUNG_NSCLC_LUAD	Establishment of epithelial cell apical/basal polarity →	-0.150	-0.018	<.001	<.001	3	6
LUNG_SCLC	ER-nucleus signaling pathway →	+0.070	+0.031	<.001	.003	3	6
BREAST	Sperm motility →	-0.070	-0.065	.001	.007	2	6
LUNG_NSCLC_LUAD	Negative regulation of endoplasmic reticulum unfolded protein response →	+0.051	+0.012	.003	<.001	3	5
LARGE_INTESTINE	Endodermal cell differentiation →	-0.116	-0.040	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,374 associations by consensus.

Negative regulation of actin nucleation by PBOV1 expression — BREAST

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